منابع مشابه
Clinical trial subgroups: challenges and opportunities in describing the benefits of therapy.
Heart disease is the leading cause of death in women in the United States.1 To combat this phenomenon, professional guidelines for primary and secondary prevention as well as sex-specific guidelines for women have been developed and promulgated.2–4 Despite these efforts, there remains some controversy surrounding the benefits of statin therapy in women,5 although a 2004 meta-analysis clearly de...
متن کاملPsoriatic arthritis: clinical subgroups and histocompatibility antigens.
Histocompatibility antigens were determined in 60 patients with psoriatic arthritis. The patients were divided into clinical subgroups according to axial or peripheral joint involvement, disease severity based on number of peripheral joints involved, and the presence or absence of bone erosions. The total group showed a significant increase in frequency of HLA-A1, B17, B27, and DR7 when compare...
متن کاملClinical Subgroups in Bilateral Meniere Disease
Meniere disease (MD) is a heterogeneous clinical condition characterized by sensorineural hearing loss, episodic vestibular symptoms, and tinnitus associated with several comorbidities, such as migraine or autoimmune disorders (AD). The frequency of bilateral involvement may range from 5 to 50%, and it depends on the duration of the disease. We have performed a two-step cluster analysis in 398 ...
متن کاملDiscriminant Analysis (proc Discrim) to Separate a Study Population by Treatment Subgroups in a Clinical Trial with a New Antidepressant
Data were evaluated from a pilot phase 2 clinical trial (N=55) with a new antidepressant and multivariate discriminant analysis (PROC DISCRIM) was used to separate the drug-treated from placebo populations by treatment subgroups. The list of variables for discriminant analysis included the percent of change from baseline for the primary efficacy variable (21-item Hamilton Depression Rating Scal...
متن کاملIdentifying subgroups of patients with acute/subacute "nonspecific" low back pain: results of a randomized clinical trial.
STUDY DESIGN Randomized clinical trial. OBJECTIVE Compare outcomes of patients with low back pain receiving treatments matched or unmatched to their subgrouping based on initial clinical presentation. SUMMARY OF BACKGROUND DATA Patients with "nonspecific" low back pain are often viewed as a homogeneous group, equally likely to respond to any particular intervention. Others have proposed met...
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ژورنال
عنوان ژورنال: Circulation: Cardiovascular Quality and Outcomes
سال: 2011
ISSN: 1941-7713,1941-7705
DOI: 10.1161/circoutcomes.111.961128